2-(Acetylamino)-3-phenyl-2-propenoic acid → N-Acetyl-L-phenylalanine

Participants

Reaction Steps

With the catalyst prepared as in example 7 there have been reduced 0.725 g of 3-acetoxy, 4-methoxy, alpha-acetaminocinnamic acid dissolved in 25 mls of anhydrous ethanol. The reaction has been carried out in an autoclave (glass) with a hydrogen pressure of 2 atm at room temperature. There has been obtained 3-acetoxy, 4-methoxy, N-acetylphenylalanine with an optical yield of 58%. [α]D22 =+12.8 (c=1, acetone) the [α]D22 (c=1, acetone) of enantiomerically pure 3-acetoxy, 4-methoxy N-acetylphenylalanine=22.

Provenance & Evidence