HCID 20541536, compound → HCID 20541535, compound

HRID 1065172Notes

Reaction equation

HRID 1065172 reaction equation
[CH3:1][Si:2]([CH3:12])([CH3:11])[C:3]#[C:4][C:5](=[O:10])[CH2:6][CH2:7][CH2:8][Cl:9].[CH2:13]([Mg]Br)[C:14]#[CH:15]>>[Cl:9][CH2:8][CH2:7][CH2:6][C:5]([OH:10])([C:4]#[C:3][Si:2]([CH3:1])([CH3:11])[CH3:12])[CH2:15][C:14]#[CH:13]

Participants

3

Reactant 2

HCID 20541536HCID 20541536, compoundHCID 178455849HCID 178455849, compound

Product 1

HCID 20541535HCID 20541535, compound

Procedure

In the manner described hereinabove in Reference Example 11, 1-trimethylsilyl-3-oxo-6-chloro-1-hexyne is reacted with propargyl magnesium bromide to give 7-chloro-4-hydroxy-4-trimethylsilylethynyl-1-heptyne.

Sources & evidence

ORD record
ord-f87f1156736343258e96ebf71307f7ab
Source dataset
uspto-grants-1982_05
Patent number
US04328359

Reaction notes

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