2-Fluoroaniline → 4-Bromo-2-fluoroaniline

Participants

Reaction Conditions

Reaction Steps

In methylene chloride (200 ml) was dissolved 2-fluoroaniline (51.0 g) and, under cooling at 0° C. and stirring N-bromosuccinimide (81.7 g) was added in small installments over a period of an hour. The mixture was further stirred for 20 minutes, after which it was washed with cold water and dried over anhydrous sodium sulfate. The methylene chloride layer was concentrated and the resultant oil was distilled under reduced pressure. By the above procedure, there was obtained 2-fluoro-4-bromoaniline as an oil boiling at 75°-80° C./0.3 mmHg.

Provenance & Evidence