Acetone → HCID 12959702, compound

HRID 1065189Notes

Reaction equation

HRID 1065189 reaction equation
[CH2:1]([N:8]1[C:13](=[O:14])[CH:12]2[CH2:15][CH2:16][CH2:17][C:10](=[CH:11]2)C1=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:19][C:20]1[CH:26]=[C:25]([Cl:27])[CH:24]=[CH:23][C:21]=1[NH2:22].C[C:29](C)=[O:30]>>[CH2:1]([NH:8][C:13](=[O:14])[C:12]1[CH2:11][CH2:10][CH2:17][CH2:16][C:15]=1[C:29]([NH:22][C:21]1[CH:23]=[CH:24][C:25]([Cl:27])=[CH:26][C:20]=1[F:19])=[O:30])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 180AcetoneHCID 938984-Chloro-2-fluoroanilineHCID 20541558HCID 20541558, compound

Product 1

HCID 12959702HCID 12959702, compound

Procedure

In acetone (50 ml) was dissolved N-benzyl-3,4,5,6-tetrahydroisophthalimide (2.4 g), followed by addition of 2-fluoro-4-chloroaniline (1.5 g). The mixture was stirred at 40°-50° C. for 2 hours, after which time the precipitate was recovered by filtration and washed with acetone. Yield 3.0 g.; m.p. 121°-123° C.

Workup

  1. filtrationafter which time the precipitate was recovered by filtration
  2. washwashed with acetone

Sources & evidence

ORD record
ord-0a781abe073442879ee72ab5d9f3378e
Source dataset
uspto-grants-1982_05
Patent number
US04328367

Reaction notes

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