Acetone → N~1~-(4-Chloro-2-fluorophenyl)cyclohex-1-ene-1,2-dicarboxamide

Participants

Reaction Steps

In acetone (100 ml) was dissolved N-(2-fluoro-4-chlorophenyl)-3,4,5,6-tetrahydroisophthalimide (22.5 g), and under cooling, 25% aqueous ammonia (5.8 g) was added dropwise over a period of about one minute, the temperature of the system being maintained below 25° C. The mixture was further stirred for 30 minutes, after which the precipitate was recovered by filtration and washed with a small amount of cold acetone. Yield 22.2 g; m.p. 150°-151° C.

Provenance & Evidence