Acetic Anhydride → HCID 12959730, compound

HRID 1065191Notes

Reaction equation

HRID 1065191 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][NH:5][C:6](=[O:24])[C:7]1[CH2:23][CH2:22][CH2:21][CH2:20][C:8]=1[C:9]([NH:11][C:12]1[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][C:13]=1[F:19])=[O:10].[C:25](OC(=O)C)(=[O:27])[CH3:26]>N1C=CC=CC=1>[C:25]([O:1][CH2:2][CH2:3][CH2:4][NH:5][C:6](=[O:24])[C:7]1[CH2:23][CH2:22][CH2:21][CH2:20][C:8]=1[C:9]([NH:11][C:12]1[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][C:13]=1[F:19])=[O:10])(=[O:27])[CH3:26]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 12959723HCID 12959723, compound

Product 1

HCID 12959730HCID 12959730, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

In pyridine (20 ml) was dissolved N-(3-hydroxypropyl)N'-(2-fluoro-4-chlorophenyl)-3,4,5,6-tetrahydrophthalamide (1.5 g), followed by addition of acetic anhydride (10 ml). The mixture was stirred at room temperature for 30 minutes. The reaction mixture was poured into 200 ml of ice-water and, after stirring, the precipitate was recovered by filtration and rinsed with water. After drying, it was recrystallized from ethyl acetate-n-hexane. Yield 0.9 g; m.p. 127°-128° C.

Workup

  1. stirringafter stirring
  2. filtrationthe precipitate was recovered by filtration
  3. washrinsed with water
  4. customAfter drying
  5. customit was recrystallized from ethyl acetate-n-hexane

Sources & evidence

ORD record
ord-cc2cc03a26734973b69e2fe03c945bf7
Source dataset
uspto-grants-1982_05
Patent number
US04328367

Reaction notes

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