Diisopropyl Ether → HCID 131712710, compound

Participants

Reaction Steps

A mixture of 870 mg of the syn isomer of benzhydryl 3-acetoxymethyl-7-[2-(2-tritylamino-4-thiazolyl)-2-(2-iodoethoxyimino)-acetamido]-ceph-3-eme-4-carboxylate [described in Belgium Pat. No. 875,217], 131 mg of thiourea and 1.7 ml of anhydrous hexamethylphosphorotriamide was stirred for 32 hours and 75 ml of isopropyl ether were added thereto with stirring. The mixture was decanted and 45 ml of ethyl ether were added thereto. The mixture was vacuum filtered to obtain 1.229 g of solvated syn isomer of benzhydryl 3-acetoxymethyl-7-[2-(2-tritylamino-4-thiazolyl)-2-(2-aminoiminomethylthioethoxyimino)-acetamido]-ceph-3-eme-4-carboxylate hydroiodide melting at ≃100° C.

Provenance & Evidence