HCID 12850595, compound → HCID 12850594, compound

Participants

Reaction Steps

To the solution of 3.47 g of 1-[1-[2-(1,4-benzoxathian-2-yl)-ethyl]-4-piperidyl]-2-imidazolidinone (Example 5, No. 8) in 10 ml of dioxane and 10 ml of methanol, the solution of 2.8 g of sodium metaperiodate in 20 ml of water is added dropwise while stirring at room temperature. After 2 hours the mixture is evaporated, the residue taken up in water and the mixture extracted with methylene chloride. The extract is washed with saturated aqueous sodium chloride, dried, evaporated and the residue recrystalized from isopropanol, to yield the 1-[1-[2-(4-oxo-1,4-benzooxathian-2-yl)-ethyl]-4-piperidyl]-2-imidazolidinone; m.p. 145°.

Provenance & Evidence