HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 1-[1-[2-(6,7-Dichloro-1,4-benzodioxan-2-yl)-ethyl]-4-piperidyl]-2-imidazolidinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 2-(2-Tosyloxyethyl)-6,7-dichloro-1,4-benzodioxan | HCID 12850604 | — |
| Reactant | 1-(Piperidin-4-yl)imidazolidin-2-one | HCID 13031757 | — |
| Solvent | Methyl Isobutyl Ketone | HCID 7909 | — |
| Product | 1-[1-[2-(6,7-Dichloro-1,4-benzodioxan-2-yl)-ethyl]-4-piperidyl]-2-imidazolidinone | HCID 12850592 | — |
Reaction Steps
The mixture of 4.0 g of 2-(2-tosyloxyethyl)-6,7-dichloro-1,4-benzodioxan, 1.69 g of 1-(4-piperidyl)-2-imidazolidinone, 10 g of ahydrous sodium carbonate and 100 ml of 4-methyl-2-pentanone is stirred and refluxed for 2 days. It is filtered, evaporated and the residue recrystallized from acetone, to yield the 1-[1-[2-(6,7-dichloro-1,4-benzodioxan-2-yl)-ethyl]-4-piperidyl]-2-imidazolidinone melting at 165°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04329348 |
| Source dataset | uspto-grants-1982_05 |
| ORD ID | ord-fe249e3b45b5408c9008579f5cb8c758 |
| Source note | uspto-grants-1982_05 |