反应详情

Thionyl chloride (31 ml) was added dropwise to methanol (210 ml) at -70°. The solution was stirred for 10 mins and then 3-(4-carboxyphenyl)-1, 1-dimethylpropanamine hydrochloride (20 g) in methanol was added dropwise. The reaction mixture was allowed to warm to ambient temperature and then heated under reflux for 1 h. The solvent was evaporated, the residue partitioned between potassium carbonate and ether and the organic layer dried. Removal of the solvent gave the title compound, as an oil.

1. temperatureheated
2. temperatureunder reflux for 1 h
3. customThe solvent was evaporated
4. customthe residue partitioned between potassium carbonate and ether
5. customthe organic layer dried
6. customRemoval of the solvent