反应详情

To a refluxing solution of 2,4-diamino-6-(1-methylhydrazino)pyrimidine (500 mg) in anhydrous methanol (15 ml) was added methyl pyruvate (496 mg) over a five minute period. Reflux was continued for 5 hours after which time the solid which had separated was collected by suction filtration of the hot mixture, washed with methanol, and dried under vacuum at 70° C. to yield tan crystals of 5,7-diamino-1,3-dimethylpyrimido(4,5-c)pyridazine-4(1H)-one (508 mg; 76% of theoretical yield; m.p.>275° C.).

1. temperatureReflux
2. customafter which time the solid which had separated
3. filtrationwas collected by suction filtration of the hot mixture
4. washwashed with methanol
5. customdried under vacuum at 70° C.