Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sulfurmycin A | HCID 155836 | — |
| Reactant | Auramycin B | HCID 155837 | — |
| Reactant | Methyl 2,5,7-trihydroxy-2-methyl-6,11-dioxo-4-({2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-(6-methyl-5-oxooxan-2-yl)hexopyranosyl]-3-(dimethylamino)hexopyranosyl}oxy)-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate | HCID 155838 | — |
| Reactant | sulfurmycin B | HCID 155839 | — |
| Product | HCID 101282619 | HCID 101282619 | — |
Reaction Steps
A 500 ml Erlenmeyer flask with 100 ml of vegetative culture of Streptomyces galilaeus OBB-111, obtained by a process analogous to that described in Example 1, containing auramycin A, auramycin B, sulfurmycin A and sulfurmycin B, was allowed to stand at room temperature for 12 hours and extracted with 200 ml of a solvent mixture of chloroform and methanol (1:1, v/v). The chloroform layer was separated, concentrated in vacuo and chromatographed by thin layer chromatography (toluene/methanol=20:1, v/v). The bands containing 7-deoxysulfurmycinone and 7-deoxyauramycinone were scraped off, extracted with chloroform and concentrated in vacuo to dryness to give 1.4 mg of pure 7-deoxysulfurmycinone and 1.2 mg of pure 7-deoxyauramycinone, respectively.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04329339 |
|---|
| Source dataset | uspto-grants-1982_05 |
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| ORD ID | ord-ef63508474144543b688cdc271bc0769 |
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| Source note | uspto-grants-1982_05 |
|---|
