Thionyl Chloride → HCID 20540243, compound

HRID 1065265Notes

Reaction equation

HRID 1065265 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([C:19]([OH:21])=O)[CH2:18][CH2:17][C:12]3([O:16][CH2:15][CH2:14][O:13]3)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.S(Cl)([Cl:24])=O>C1C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([C:19]([Cl:24])=[O:21])[CH2:18][CH2:17][C:12]3([O:16][CH2:15][CH2:14][O:13]3)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 122302471,4-Dioxaspiro[4.5]decane-8-carboxylic acid, 8-(4-methoxyphenyl)-

Product 1

HCID 20540243HCID 20540243, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A mixture of 245 parts of 8-(4-methoxyphenyl)-1,4-dioxaspiro[4,5]decane-8-carboxylic acid, 150 parts of thionyl chloride and 1350 parts of benzene is stirred first for 30 minutes at room temperature and further for 4 hours at reflux. The reaction mixture is evaporated, yielding 275 parts of 8-(4-methoxyphenyl)-1,4-dioxaspiro[4,5]decane-8-carbonyl chloride as a residue.

Workup

  1. temperatureat reflux
  2. customThe reaction mixture is evaporated

Sources & evidence

ORD record
ord-de1783506d904adfbf40d84d22147b0c
Source dataset
uspto-grants-1982_05
Patent number
US04329353

Reaction notes

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