Ethanol → HCID 20540238, compound

HRID 1065267Notes

Reaction equation

HRID 1065267 reaction equation
C([OH:3])C.[F:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2([C:21](Cl)=[O:22])[CH2:20][CH2:19][C:14]3([O:18][CH2:17][CH2:16][O:15]3)[CH2:13][CH2:12]2)=[CH:7][CH:6]=1.C[C:25]1[CH:30]=CC=CC=1>>[F:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2([C:21]([O:22][CH2:30][CH3:25])=[O:3])[CH2:20][CH2:19][C:14]3([O:18][CH2:17][CH2:16][O:15]3)[CH2:13][CH2:12]2)=[CH:7][CH:6]=1

Participants

4

Reactant 3

HCID 702EthanolHCID 1140TolueneHCID 20540206HCID 20540206, compound

Product 1

HCID 20540238HCID 20540238, compoundYield 90.6%

Procedure

To 120 parts of absolute ethanol is added dropwise a solution of 102 parts of 8-(4-fluorophenyl)-1,4-dioxaspiro[4,5]decane-8-carbonyl chloride in 270 parts of methylbenzene, while cooling. Upon completion, the whole is stirred for 24 hours at reflux temperature. The reaction mixture is cooled, washed with water, dried, filtered and evaporated, yielding 95 parts (90.6%) of ethyl 8-(4-fluorophenyl)-1,4-dioxaspiro[4,5]decane-8-carboxylate as a residue.

Workup

  1. temperaturewhile cooling
  2. temperatureat reflux temperature
  3. temperatureThe reaction mixture is cooled
  4. washwashed with water
  5. customdried
  6. filtrationfiltered
  7. customevaporated

Sources & evidence

ORD record
ord-0ce6f0b7ff304566858c874e9ee01c1b
Source dataset
uspto-grants-1982_05
Patent number
US04329353

Reaction notes

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