反应详情

To 120 parts of absolute ethanol is added dropwise a solution of 102 parts of 8-(4-fluorophenyl)-1,4-dioxaspiro[4,5]decane-8-carbonyl chloride in 270 parts of methylbenzene, while cooling. Upon completion, the whole is stirred for 24 hours at reflux temperature. The reaction mixture is cooled, washed with water, dried, filtered and evaporated, yielding 95 parts (90.6%) of ethyl 8-(4-fluorophenyl)-1,4-dioxaspiro[4,5]decane-8-carboxylate as a residue.

1. temperaturewhile cooling
2. temperatureat reflux temperature
3. temperatureThe reaction mixture is cooled
4. washwashed with water
5. customdried
6. filtrationfiltered
7. customevaporated