Water → HCID 12943034, compound

HRID 1065278Notes

Reaction equation

HRID 1065278 reaction equation
[C:1](OC(=O)C)(=O)C.[OH-].[Na+].O.[CH3:11][S:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][C:20]2[CH:25]=[CH:24][C:23]([NH:26][C:27](=[O:29])[CH3:28])=[CH:22][CH:21]=2)=[CH:15][C:14]=1C>C(O)C>[CH3:11][S:12][C:13]1[CH:14]=[CH:15][C:16]([O:19][C:20]2[CH:21]=[CH:22][C:23]([NH:26][C:27](=[O:29])[CH3:28])=[CH:24][CH:25]=2)=[C:17]([CH3:1])[CH:18]=1

Participants

6

Reactant 4

HCID 962WaterHCID 7918Acetic AnhydrideHCID 14798Sodium HydroxideHCID 20540331HCID 20540331, compound

Product 1

HCID 12943034HCID 12943034, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

This solid was dissolved in ethanol and treated with first excess of acetic anhydride, and then, with stirring, with dilute aqueous sodium hydroxide solution until strongly alkaline. After about 10 minutes, the reaction was treated with water to faint turbidity and left to stand. Platelets of the product 4-(4-acetamidophenoxy)-2-methylphenyl methyl sulphide, come out of solution slowly, melting point 99.6° to 101° C. On recrystallisation from ethanol-water, analytical samples were obtained melting between 101.4° and 102.1° C.

Workup

  1. waitleft
  2. customOn recrystallisation from ethanol-water
  3. customanalytical samples were obtained
  4. custommelting between 101.4° and 102.1° C.

Sources & evidence

ORD record
ord-2a4b8b8b43564c5fbb0b319d17e3ad2e
Source dataset
uspto-grants-1982_05
Patent number
US04329365

Reaction notes

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