Ethanol → HCID 12833329, compound

Participants

Reaction Conditions

Reaction Steps

22 g. (76.5 mmol.) of 2-(4'-chloro-β-aminostyryl)nicotinic acid N-methylamide (Compound XIX) were dissolved in 80 ml. of tetrahydrofuran and 40 ml. of ethanol and a mixture of 40 ml. of acetic acid and 40 ml. of water was added. The reaction mixture was stirred at 40° C. for 4 hours. The reaction mixture was then made basic to pH 9 with sodium hydroxide solution and extracted with diethyl ether, ethyl acetate and methylene chloride. The three organic extracts were combined, treated with charcoal, dried over anhydrous magnesium sulfate and concentrated at reduced pressure to obtain a yellow solid which was recrystallized from ethanol to obtain the product as a yellow green solid, m.p. 162°-163° C.

Provenance & Evidence