Sodium Hydroxide → HCID 20540312, compound

HRID 1065305Notes

Reaction equation

HRID 1065305 reaction equation
[OH-].[Na+].[C:3]([OH:6])(=[S:5])[CH3:4].[C:7]([NH:11][C:12](=[O:15])[CH2:13]Cl)(=[O:10])[CH2:8][CH3:9]>CO>[C:7]([NH:11][C:12](=[O:15])[CH2:13][S:5][C:3](=[O:6])[CH3:4])(=[O:10])[CH2:8][CH3:9]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 23424171N-(Chloroacetyl)propanamideHCID 178418634HCID 178418634, compound

Product 1

HCID 20540312HCID 20540312, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Nitrogen was bubbled through 4.0 g. (0.1 mole) of sodium hydroxide in 200 ml. of methanol and to this there was added 7.1 ml. (0.1 mole) of thioacetic acid and then 16.0 g. (0.1 mole) of N-propionyl-2-chloroacetamide. The reaction mixture was stirred at ambient temperature for 2 hours and then stripped in vacuo and filtered. The product was dissolved in boiling water, treated with characoal, filtered and dried in vacuo. A yield of 6.0 g. of white crystalline product was obtained.

Workup

  1. customNitrogen was bubbled through 4.0 g
  2. filtrationfiltered
  3. dissolutionThe product was dissolved
  4. additiontreated with characoal
  5. filtrationfiltered
  6. customdried in vacuo
  7. customof white crystalline product was obtained

Sources & evidence

ORD record
ord-5748a433e24d439f8b014e80f768ce31
Source dataset
uspto-grants-1982_05
Patent number
US04329363

Reaction notes

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