6-Hydroxy-3,4-dihydro-2(1H)-quinolinone → 6-(4-Phenylsulfonyl-butoxy)-3,4-dihydro-carbostyril

HRID 1065313Notes

Reaction equation

HRID 1065313 reaction equation
O[C:2]1C=C2C(=CC=1)NC(=O)CC2.N1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[S:19]([CH2:22][CH2:23][CH2:24][CH2:25][O:26][C:27]1[CH:28]=[C:29]2[C:34](=[CH:35][CH:36]=1)[NH:33][C:32](=[O:37])[CH2:31][CH2:30]2)(=[O:21])=[O:20]>>[C:14]1([S:19]([CH2:22][CH2:23][CH2:24][CH2:25][O:26][C:27]2[CH:28]=[C:29]3[C:34](=[CH:35][CH:36]=2)[NH:33][C:32](=[O:37])[CH2:31][CH2:30]3)(=[O:21])=[O:20])[CH:2]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 27740406-Hydroxy-3,4-dihydro-2(1H)-quinolinoneHCID 205400716-[4-(2-Pyridyl-sulfonyl)-butoxy]-3,4-dihydro-carbostyril

Product 1

HCID 205400496-(4-Phenylsulfonyl-butoxy)-3,4-dihydro-carbostyril

Procedure

Prepared analogous to Example 4 from 6-hydroxy-3,4-dihydro-carbostyril and 4-phenylsulfonyl-butyl bromide (prepared from 4-(phenylmercapto)-butyl bromide by oxidation analogous to Example 3).

Sources & evidence

ORD record
ord-6402bd8f68a145f18fba70b6d0e48827
Source dataset
uspto-grants-1982_05
Patent number
US04329347

Reaction notes

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