4-Fluorothiophenol → 6-[4-(4-Fluorophenyl-mercapto)-butoxy]-3,4-dihydro-carbostyril

HRID 1065314Notes

Reaction equation

Br[CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[NH:13][C:12](=[O:17])[CH2:11][CH2:10]2.[F:18][C:19]1[CH:24]=[CH:23][C:22]([SH:25])=[CH:21][CH:20]=1>>[F:18][C:19]1[CH:24]=[CH:23][C:22]([S:25][CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]2[CH:8]=[C:9]3[C:14](=[CH:15][CH:16]=2)[NH:13][C:12](=[O:17])[CH2:11][CH2:10]3)=[CH:21][CH:20]=1

Participants

Reactant 2

HCID 677894-Fluorothiophenol

HCID 131098086-(4-Bromobutoxy)-3,4-dihydro-carbostyril

Product 1

HCID 202606526-[4-(4-Fluorophenyl-mercapto)-butoxy]-3,4-dihydro-carbostyril

Procedure

Prepared analogous to Example 1 from 6-(4-bromo-butoxy)-3,4-dihydro-carbostyril (m.p. 142°-147° C.) and 4-fluorothiophenol.

Sources & evidence

ORD record: ord-48a496678f784d2eb43409760c95e497
Source dataset: uspto-grants-1982_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04329347

Reaction notes

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