Sodium periodate → HCID 20540140, compound

HRID 1065333Notes

Reaction equation

HRID 1065333 reaction equation
[CH3:1][S:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[NH:12][C:11](=[O:16])[CH2:10][CH2:9]2.I([O-])(=O)(=O)=[O:18].[Na+]>CO.O>[CH3:1][S:2]([CH2:3][CH2:4][O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[NH:12][C:11](=[O:16])[CH2:10][CH2:9]2)=[O:18]

Participants

5

Reactant 2

HCID 23667635Sodium periodateHCID 53974171HCID 53974171, compound

Product 1

HCID 20540140HCID 20540140, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent2×

Procedure

1.42 gm (0.006 mol) of 6-(2-methylmercapto-ethoxy)-3,4-dihydro-carbostyril were suspended in 12 ml of methanol, and a solution of 1.71 gm (0.008 mol) of sodium metaperiodate in 8 ml of water was added. The reaction mixture was stirred for 1.5 hours; at the beginning a distinct warming of the reaction mixture was noted. Subsequently, the mixture was diluted with a little water and exhaustively extracted with chloroform. The evaporation residue of the chloroform extract was recrystallized from ethyl acetate by addition of a little ethanol.

Workup

  1. temperatureat the beginning a distinct warming of the reaction mixture
  2. extractionexhaustively extracted with chloroform
  3. extractionThe evaporation residue of the chloroform extract
  4. customwas recrystallized from ethyl acetate by addition of a little ethanol

Sources & evidence

ORD record
ord-ee261818b7ca4dbc914ecef31c9710d5
Source dataset
uspto-grants-1982_05
Patent number
US04329347

Reaction notes

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