Sodium Methoxide → HCID 20540127, compound

HRID 1065340Notes

Reaction equation

HRID 1065340 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[NH:13][C:12](=[O:17])[CH2:11][CH2:10]2.[SH:18][C:19]1[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=1.C[O-].[Na+]>CO.O>[N:22]1[CH:23]=[CH:24][C:19]([S:18][CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]2[CH:8]=[C:9]3[C:14](=[CH:15][CH:16]=2)[NH:13][C:12](=[O:17])[CH2:11][CH2:10]3)=[CH:20][CH:21]=1

Participants

6

Reactant 3

HCID 10942334Sodium MethoxideHCID 131098086-(4-Bromobutoxy)-3,4-dihydro-carbostyrilHCID 178418431pyridine-4-thiol

Product 1

HCID 20540127HCID 20540127, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

3.0 gm of 6-(4-bromo-butoxy)-3,4-dihydro-carbostyril were added to a solution of 1.3 gm of 4-mercapto-pyridine and 2.3 gm of a 30% sodium methylate solution in 15 ml of methanol, and the mixture was stirred for 14 hours at room temperature. Subsequently, the reaction solution was diluted with 20 ml of water and the resulting precipitate was recrystallized from ethanol.

Workup

  1. customthe resulting precipitate was recrystallized from ethanol

Sources & evidence

ORD record
ord-a2a49ce08b0a4f53b632a6cde689965d
Source dataset
uspto-grants-1982_05
Patent number
US04329347

Reaction notes

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