7-Hydroxy-3,4-dihydrocarbostyril → 7-(4-Phenylsulfinyl-butoxy)-3,4-dihydro-carbostyril

HRID 1065354Notes

Reaction equation

HRID 1065354 reaction equation
[OH:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][C:8](=[O:12])[NH:9]2)=[CH:4][CH:3]=1.[C:13]1([S:19]([CH2:21][CH2:22][CH2:23][CH2:24]Br)=[O:20])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[C:13]1([S:19]([CH2:21][CH2:22][CH2:23][CH2:24][O:1][C:2]2[CH:11]=[C:10]3[C:5]([CH2:6][CH2:7][C:8](=[O:12])[NH:9]3)=[CH:4][CH:3]=2)=[O:20])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 27857587-Hydroxy-3,4-dihydrocarbostyrilHCID 545301224-Phenylsulfinylbutylbromide

Product 1

HCID 202606387-(4-Phenylsulfinyl-butoxy)-3,4-dihydro-carbostyril

Procedure

Prepared analogous to Example 4 from 7-hydroxy-3,4-dihydro-carbostyril (see N. Shigematsu et al., Chem. Pharm. Bull. 1961, 970-975) and 4-phenylsulfinyl-butyl bromide.

Sources & evidence

ORD record
ord-892b45da32bc4d2e96a525a8393b1ef6
Source dataset
uspto-grants-1982_05
Patent number
US04329347

Reaction notes

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