反应详情

100 mgm of 5-(4-phenylsulfonyl-butoxy)-3,4-dihydro-carbostyril were refluxed with 30 mgm of palladium-on-charcoal and 1 ml of mesitylene. After 3.5 hours, another 30 mgm of palladium-on-charcoal were added, and the mixture was heated for 9 hours more. Subsequently, the reaction mixture was filtered while still hot, the filtrate was evaporated, and the residue was chromatographed on a silica gel column with a mixture of benzene/ethanol/conc. ammonia=75/25/3. Besides unreacted starting material, 9 mgm of 5-(4-phenylsulfonyl-butoxy)-carbostyril were obtained.

1. temperaturethe mixture was heated for 9 hours more
2. filtrationSubsequently, the reaction mixture was filtered while still hot, the filtrate
3. customwas evaporated
4. customthe residue was chromatographed on a silica gel column with a mixture of benzene/ethanol/conc
5. customwere obtained