Acetic Anhydride → HCID 20540047, compound

HRID 1065458Notes

Reaction equation

HRID 1065458 reaction equation
[NH:1]([C:5]1[C:14]([O:15][CH2:16][CH2:17][CH2:18][CH2:19]Br)=[CH:13][CH:12]=[C:11]2[C:6]=1[CH:7]=[CH:8][C:9](=[O:21])[NH:10]2)[C:2]([CH3:4])=[O:3].[N+](C1C(OCCCCBr)=CC=C2C=1C=CC(=O)N2)([O-])=O.C(OC(=O)C)(=O)C.[C:49]1([SH:55])[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=1>C(O)(=O)C.[Zn]>[NH:1]([C:5]1[C:14]([O:15][CH2:16][CH2:17][CH2:18][CH2:19][S:55][C:49]2[CH:54]=[CH:53][CH:52]=[CH:51][CH:50]=2)=[CH:13][CH:12]=[C:11]2[C:6]=1[CH:7]=[CH:8][C:9](=[O:21])[NH:10]2)[C:2]([CH3:4])=[O:3]

Participants

7

Reactant 4

HCID 7918Acetic AnhydrideHCID 7969ThiophenolHCID 20540100HCID 20540100, compoundHCID 20540130HCID 20540130, compound

Product 1

HCID 20540047HCID 20540047, compound

Reagents, catalysts & solvents 2

HCID 23994ZincCatalystHCID 176Acetic AcidSolvent

Procedure

Prepared analogous to Example 122 from 5-acetamino-6-(4-bromo-butoxy)-carbostyril [prepared by reduction with zinc in acetic acid of 5-nitro-6-(4-bromo-butoxy)-carbostyril in the presence of acetic acid anhydride] and thiophenol.

Sources & evidence

ORD record
ord-fef255176de64edcad8d97140d6b0840
Source dataset
uspto-grants-1982_05
Patent number
US04329347

Reaction notes

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