Hydrochloric Acid → HCID 20540393, compound

Participants

Reaction Steps

To the suspension of 5.0 g of racemic 1-[4-(4-carbamoylbenzyloxy)-phenyl]-2-(3,3-diphenylpropylamino)-propane (Example 10/7) in 75 ml of tetrahydrofuran, 70 ml of 1-molar diborane in tetrahydrofuran are added dropwise while stirring under nitrogen at 0°. It is refluxed for 18 hours, cooled to 0° again and 30 ml of water are added dropwise, followed by 15 ml of concentrated hydrochloric acid. The mixture is evaporated, warmed with 50 ml of methanol, evaporated again and the residue is recrystallized from ethanol, to yield the 1-(4-(4-aminomethylbenzyloxy)-phenyl]-2-(3,3-diphenylpropylamino)-propane dihydrochloride melting at 259°-262°.

Provenance & Evidence