Methanol → HCID 70539806, compound

Participants

Reaction Steps

The mixture of 2.4 g of 1-[4-(4-carbamoylbenzyloxy)-phenyl]-2-(3,3-diphenylpropylamino)-propane, 3.6 g of boron trifluoride etherate and 20 ml of methanol is heated in a sealed tube at 115° for 6 hours. After cooling it is diluted with water, extracted with ethyl acetate, the extract dried, concentrated and the concentrate neutralized with maleic acid in ethyl acetate, to yield the 1-[4-(4-carbomethoxybenzyloxy)-phenyl]-2-(3,3-diphenylpropylamino)-propane maleate melting at 172°-175°.

Provenance & Evidence