Hydrochloric Acid → HCID 20540361, compound

Participants

Reaction Steps

To the suspension of 11.2 g of dl-1-(p-benzyloxyphenyl)-2-(3,3-diphenylpropionamido)-propane in 200 ml of tetrahydrofuran, 150 ml of 1 molar borane in tetrahydrofuran are added dropwise while stirring under nitrogen at 0°. The mixture is refluxed overnight, cooled to 0° and treated dropwise with 150 ml of methanol, followed by 30 ml of concentrated hydrochloric acid. The mixture is evaporated, again treated with 150 ml of methanol, warmed to 50° and evaporated. The resulting white solid is recrystallized from isopropanol containing a little methanol to afford the dl-1-(p-benzyloxyphenyl)-2-(3,3-diphenylpropylamino)-propane hydrochloride, melting at 187°-190°.

Provenance & Evidence