3,3-Diphenylacrolein → HCID 13065282, compound

Participants

Reaction Steps

The starting material is prepared as follows: The solution of 12 g of dl-p-benzyloxyamphetamine, and 10.4 g of β-phenyl-cinnamaldehyde in 300 ml of absolute ethanol is treated dropwse with the solution of 3 g of sodium borohydride in 6.7 ml of water while stirring. It is refluxed for 18 hours, concentrated to remove most of the ethanol and diluted with water. The mixture is extracted with ethyl acetate and the organic layer washed with brine, dried and evaporated, to yield the dl-1-(p-benzyloxyphenyl)-2-(3,3-diphenylallylamino)-propane; its maleate melts at 177°-178°.

Provenance & Evidence