Morpholine → HCID 70550960, compound

HRID 1065480Notes

Reaction equation

HRID 1065480 reaction equation
[N+:1]([C:4]1[CH:19]=[CH:18][C:7]([CH:8]=[N:9][NH:10][C:11]2[N:12]=[N:13][C:14](Cl)=[CH:15][CH:16]=2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[NH:20]1[CH2:25][CH2:24][O:23][CH2:22][CH2:21]1>CN(C)P(=O)(N(C)C)N(C)C>[N+:1]([C:4]1[CH:19]=[CH:18][C:7]([CH:8]=[N:9][NH:10][C:11]2[N:12]=[N:13][C:14]([N:20]3[CH2:25][CH2:24][O:23][CH2:22][CH2:21]3)=[CH:15][CH:16]=2)=[CH:6][CH:5]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 8083MorpholineHCID 593142HCID 593142, compound

Product 1

HCID 70550960HCID 70550960, compoundYield 85.3%

Reagents, catalysts & solvents 1

HCID 12679HexamethylphosphoramideSolvent

Procedure

The mixture of 5.55 g (20 mmoles) of 4-nitrobenzylidene-(6-chloro-3-pyridazinyl)-hydrazine [prepared by the process described in Step a:], 7.66 g (88 mmoles) of morpholine and 5.5 ml of hexamethylphosphoric cid triamide is heated at 150° C. for 24 hours. After cooling, the mixture is triturated with 56 ml of water, the precipitate is filtered, washed with cold ethanol and dried to give 5.6 g (85%) of the named compound; m.p. 245° C. (with decomposition).

Workup

  1. customprepared by the process
  2. temperatureAfter cooling
  3. customthe mixture is triturated with 56 ml of water
  4. filtrationthe precipitate is filtered
  5. washwashed with cold ethanol
  6. customdried

Sources & evidence

ORD record
ord-50e66ff8481545c1857329f3e3d3d8fc
Source dataset
uspto-grants-1982_05
Patent number
US04329457

Reaction notes

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