Morpholine → HCID 56974780, compound

HRID 1065481Notes

Reaction equation

HRID 1065481 reaction equation
C(O)(=O)C.[CH3:5][N:6]([C:17]1[N:18]=[N:19][C:20](Cl)=[CH:21][CH:22]=1)[N:7]=[C:8]1[CH2:13][CH:12]2[C:14]([CH3:16])([CH3:15])[CH:9]1[CH2:10][CH2:11]2.[NH:24]1[CH2:29][CH2:28][O:27][CH2:26][CH2:25]1>>[CH3:5][N:6]([C:17]1[N:18]=[N:19][C:20]([N:24]2[CH2:29][CH2:28][O:27][CH2:26][CH2:25]2)=[CH:21][CH:22]=1)[N:7]=[C:8]1[CH2:13][CH:12]2[C:14]([CH3:16])([CH3:15])[CH:9]1[CH2:10][CH2:11]2

Participants

3

Reactant 2

HCID 8083MorpholineHCID 86738366HCID 86738366, compound

Product 1

HCID 56974780HCID 56974780, compoundYield 92.6%

Conditions

Temperature
145 °C

Procedure

A mixture of 33.9 g (0.1 moles) of 1,7,7-trimethyl-2-bicyclo(2,2,1)heptylidene-(6-chloro-3-pyridazinyl)-hydrazine acetate and 43.5 g /0.5 moles/ of morpholine is reacted while stirring at 145° C. for 8 hours. Then the excess of morpholine is removed under vacuum, the residue is triturated with 100 ml of water, filtered and dried to give 30.5 g (92.6%) of the title compound; m.p. 188°-190° C. (after recrystallization from ethanol).

Workup

  1. customis reacted
  2. customThen the excess of morpholine is removed under vacuum
  3. customthe residue is triturated with 100 ml of water
  4. filtrationfiltered
  5. customdried

Sources & evidence

ORD record
ord-2c1e4d48017143858575039ed0ef48a7
Source dataset
uspto-grants-1982_05
Patent number
US04329457

Reaction notes

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