Hydrochloric Acid → HCID 20540670, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4.4 g (15 mmole) of ethyl 3-acetyl-5-(bromomethyl)-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylate 2.5 g (16 mmole) of 4-phenylpiperidine, 2.1 g (15 mmole) of potassium carbonate and 75 ml of ethanol is stirred at 25° C. for 16 hours. Water (100 ml) is added and a precipitate forms. This is separated by filtration and washed with water. It is then suspended in 2-propanol and 1 equivalent of hydrogen chloride in 2-propanol is added. The resulting solid is separated by filtration and recrystallized from 2-propanol containing a little water to give ethyl 2,3-dihydro-5-[(4-phenyl-1-piperidinyl)methyl]-2-oxo-1H-imidazole-4-carboxylate hydrochloride melting at about 240°-241° C.

Provenance & Evidence