Acetic Acid → HCID 12890671, compound

Participants

Reaction Steps

In 200 ml. of glacial acetic acid is dissolved 1.38 g. of methyl 1-(2-tetrahydrofuryl)-1,2,3,4-tetrahydro-2,4-dioxopyrimidine-5-carboxylate and the fluorination is carried out at 18° C. to 24° C. using a gaseous mixture of fluorine (15 V/V %) and nitrogen. When the mixed gas equivalent to 2.2 moles of fluorine has been introduced, the absence of any residual starting material is confirmed by ultraviolet absorption spectrum. The solvent is then distilled off under reduced pressure to give a colorless syrup of methyl 6-acetoxy-5-fluoro-1-(2-tetrahydrofuryl)-1,2,3,4,5,6-hexahydro-2,4-dioxopyrimidine-5-carboxylate.

Provenance & Evidence