2-acetylamino-4-nitrophenyl gamma-N,N-dimethylaminopropyl ether → HCID 20538797, compound

HRID 1065592Notes

Reaction equation

HRID 1065592 reaction equation
[CH3:1][N:2]([CH2:4][CH2:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[CH:10][C:9]=1[NH:17][C:18](=[O:20])[CH3:19])[CH3:3]>C(O)C.[Pd]>[CH3:1][N:2]([CH2:4][CH2:5][CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][C:9]=1[NH:17][C:18](=[O:20])[CH3:19])[CH3:3]

Participants

4

Reactant 1

HCID 205388082-acetylamino-4-nitrophenyl gamma-N,N-dimethylaminopropyl ether

Product 1

HCID 20538797HCID 20538797, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

7 g of 2-acetylamino-4-nitrophenyl γ-N,N-dimethylaminopropyl ether are dissolved in 35 ml of absolute ethanol. 0.5 g of 10% strength palladium-on-charcoal is added as a catalyst and the reduction is carried out in a reaction bomb under a hydrogen pressure of 40 bars, at 60° C., for 30 minutes. After the catalyst has been removed by filtration, the alcohol is driven off in vacuo to give the expected product in the form of an oil, which will be used as such for the following step.

Workup

  1. customAfter the catalyst has been removed by filtration

Sources & evidence

ORD record
ord-c6b2fd4892264ba99f6a41390145ecc9
Source dataset
uspto-grants-1982_05
Patent number
US04330292

Reaction notes

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