Butyl isocyanate → HCID 12850187, compound

Participants

Reaction Steps

2-(4-((3-Chloro-5-(trifluoromethyl)-2-pyridyl)-oxy)phenoxy)propanamide (2.24 grams (g), 0.006 mole) was dissolved in dry toluene (50 ml). Butyl isocyanate (1.8 g, 0.018 mole) was then added and the mixture refluxed 13 hours. At the end of this time most of the toluene was removed by distillation under reduced pressure and the residue taken up in hot heptane and treated with decolorizing carbon. After filtration and cooling the product was deposited in the form of fine white crystals, m.p. 126°-127° C.; Yield 2.1 g; 73.6%.

Provenance & Evidence