Chlorosulfonic acid → 3,5-Dichloro-2,4,6-trifluorobenzoyl fluoride

HRID 1065601Notes

Reaction equation

HRID 1065601 reaction equation
[Cl:1][C:2]1[C:3]([F:15])=[C:4]([C:11](F)(F)[F:12])[C:5]([F:10])=[C:6]([Cl:9])[C:7]=1[F:8].ClS(O)(=O)=[O:18]>>[Cl:1][C:2]1[C:3]([F:15])=[C:4]([C:5]([F:10])=[C:6]([Cl:9])[C:7]=1[F:8])[C:11]([F:12])=[O:18]

Participants

3

Reactant 2

HCID 24638Chlorosulfonic acidHCID 27825101,3-dichloro-2,4,6-trifluoro-5-(trifluoromethyl)benzene

Product 1

HCID 198504823,5-Dichloro-2,4,6-trifluorobenzoyl fluorideYield 82.1%

Procedure

A mixture of 520 g of 3,5-dichloro-2,4,6-trifluorobenzotrifluoride and 400 g of chlorosulphonic acid is heated for 4 hours, whilst stirring, as described in Example 1. 392 g of 3,5-dichloro-2,4,6-trifluorobenzoyl fluoride (82% of the theoretical yield) of boiling point 90° to 95° C./15 mbars and nD20 :1.5007 are obtained by distillation.

Workup

  1. temperatureis heated for 4 hours

Sources & evidence

ORD record
ord-43b5a139636340b7928a54e2774ec4c2
Source dataset
uspto-grants-1982_05
Patent number
US04330366

Reaction notes

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