Sodium borohydride → HCID 20539683, compound

Participants

Reaction Steps

8.7 g (0.025 mol) of 1-(6-chloro-pyridin-2-yl-oxy)-2-(4-chlorophenyl)-1-(1,2,4-triazol-1-yl)-ethan-2-one (Example 1) were dissolved in 100 ml of methanol, and 1 g (0.025 mol) of sodium borohydride was added. The mixture was heated under reflux for 30 minutes and concentrated by distilling off the solvent in vacuo, and the residue was partitioned between chloroform and water. The organic phase was separated off, extracted again by shaking with water, dried over magnesium sulphate and concentrated. 62 g (70% of theory) of 1-(6-chloro-pyridin-2-yl-oxy)-2-(4-chlorophenyl)-1-(1,2,4-triazol-1-yl)-ethan-2-ol were obtained as a viscous oil.

Provenance & Evidence