HuagongsheHuagongshe Chemistry Print Report · For research reference only
2(1H)-Quinolone, 7-hydroxy-4-methyl- → 7-[3-(4-Benzamidopiperidino)-propoxy]-4-methyl-2-oxo-1,2-dihydroquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2(1H)-Quinolone, 7-hydroxy-4-methyl- | HCID 5374442 | — |
| Reactant | N-[1-(3-Chloropropyl)piperidin-4-yl]benzamide | HCID 12799158 | — |
| Solvent | 1-Methoxyethanol | HCID 3015637 | — |
| Product | 7-[3-(4-Benzamidopiperidino)-propoxy]-4-methyl-2-oxo-1,2-dihydroquinoline | HCID 20473360 | 46% |
Reaction Steps
In a manner analogous to that described in Example 8, by the reaction of 7-hydroxy-4-methyl-2-oxo-1,2-dihydroquinoline with 3-(4-benzamido-piperidino)-propyl chloride in methoxyethanol, there is obtained, in a yield of 46% of theory, 7-[3-(4-benzamido-piperidino)-propoxy]-4-methyl-2-oxo-1,2-dihydroquinoline; m.p. 275°-276° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04330549 |
| Source dataset | uspto-grants-1982_05 |
| ORD ID | ord-69642661459b4d56961aada9205334d4 |
| Source note | uspto-grants-1982_05 |