Ammonia → 1-(3-mercapto-2-methylthio-1-oxopropyl)-4-oxo-L-proline

HRID 1065660Notes

Reaction equation

C([S:4][CH2:5][CH:6]([S:18][CH3:19])[C:7]([N:9]1[CH2:16][C:15](=[O:17])[CH2:14][C@H:10]1[C:11]([OH:13])=[O:12])=[O:8])(=O)C.N>>[SH:4][CH2:5][CH:6]([S:18][CH3:19])[C:7]([N:9]1[CH2:16][C:15](=[O:17])[CH2:14][C@H:10]1[C:11]([OH:13])=[O:12])=[O:8]

Participants

Reactant 2

HCID 222Ammonia

HCID 536857661-[3-(acetylthio)-2-methylthio-1-oxopropyl]-4-oxo-L-proline

Product 1

HCID 545315621-(3-mercapto-2-methylthio-1-oxopropyl)-4-oxo-L-proline

Procedure

The product from part (c) is hydrolyzed with concentrated ammonia according to the procedure of Example 2 to yield 1-(3-mercapto-2-methylthio-1-oxopropyl)-4-oxo-L-proline.

Sources & evidence

ORD record: ord-72146d0024084558838778564cbc016a
Source dataset: uspto-grants-1982_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04330548

Reaction notes

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