3-Acetylthiopropionyl chloride → 1-[4-(acetylthio)-1-oxobutyl]-4-oxo-L-proline

HRID 1065661Notes

Reaction equation

HRID 1065661 reaction equation
[C:1](CCCC(Cl)=S)(=[O:3])[CH3:2].[C:10]([CH2:13][CH2:14][C:15](Cl)=[S:16])(=[O:12])C.SCC(SC)C([N:23]1[CH2:30][C:29](=[O:31])[CH2:28][C@H:24]1[C:25]([OH:27])=[O:26])=O>>[C:1]([S:16][CH2:15][CH2:14][CH2:13][C:10]([N:23]1[CH2:30][C:29](=[O:31])[CH2:28][C@H:24]1[C:25]([OH:27])=[O:26])=[O:12])(=[O:3])[CH3:2]

Participants

4

Reactant 3

HCID 200413153-Acetylthiopropionyl chlorideHCID 204284874-Acetylthiobutyroyl chlorideHCID 545315621-(3-mercapto-2-methylthio-1-oxopropyl)-4-oxo-L-proline

Product 1

HCID 543554581-[4-(acetylthio)-1-oxobutyl]-4-oxo-L-proline

Procedure

Following the procedure of Example 1 but substituting 4-acetylthiobutyroyl chloride for the 3-acetylthiopropionyl chloride in part (d), one obtains 1-[4-(acetylthio)-1-oxobutyl]-4-oxo-L-proline.

Sources & evidence

ORD record
ord-259e48804c5841e58490c84baa33a91d
Source dataset
uspto-grants-1982_05
Patent number
US04330548

Reaction notes

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