Maleate(2-) → HCID 12961942, compound

HRID 1065690Notes

Reaction equation

HRID 1065690 reaction equation
[OH:1][C@@H:2]1[CH2:7][C@H:6]2[C@H:8]3[C@H:18]([CH2:19][CH2:20][C@:4]2([CH3:5])[C@H:3]1[NH:22][CH3:23])[C@:16]1([CH3:17])[C@H:11]([CH2:12][C:13](=[O:21])[CH2:14][CH2:15]1)[CH2:10][CH2:9]3.[C:24]([O-:31])(=[O:30])/[CH:25]=[CH:26]\[C:27]([O-:29])=[O:28]>>[C:24]([OH:31])(=[O:30])/[CH:25]=[CH:26]\[C:27]([OH:29])=[O:28].[OH:1][C@@H:2]1[CH2:7][C@H:6]2[C@H:8]3[C@H:18]([CH2:19][CH2:20][C@:4]2([CH3:5])[C@H:3]1[NH:22][CH3:23])[C@:16]1([CH3:17])[C@H:11]([CH2:12][C:13](=[O:21])[CH2:14][CH2:15]1)[CH2:10][CH2:9]3

Participants

3

Reactant 2

HCID 5288227Maleate(2-)HCID 12961941HCID 12961941, compound

Product 1

HCID 12961942HCID 12961942, compound

Procedure

A sample of 16α-hydroxy-17β-methylamino-5α-androstan-3-one was converted to the maleate, which was crystallised from methylene dichloride-acetone to give pure 16α-hydroxy-17β-methylamino-5α-androstan-3-one maleate as prisms, m.p. 204°-207° C., [α]DDMSO +8° (C 1.0).

Workup

  1. customwas crystallised from methylene dichloride-acetone

Sources & evidence

ORD record
ord-be134214085248e3b8c8163c3b342af7
Source dataset
uspto-grants-1982_05
Patent number
US04330539

Reaction notes

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