Potassium Hydroxide → HCID 12961951, compound

Participants

Reaction Steps

Potassium hydroxide (4.8 ml; 10 N) was added to a stirred suspension of 17β-(N-acetyl-methylamino)-5α-androstane-3β,16β-diol (4.8 g) in ethanol (96 ml) and the stirred mixture was heated under reflux for 2 h. A clear solution was obtained after 5 min., and a solid product precipitated after 30 min. The mixture was cooled, water was added, followed by brine and the product was filtered off and washed with water. Crystallisation from aqueous ethanol gave 17β-methylamino-5α-androstane-3β,16β-diol as prisms (3.5 g), m.p. 241°-253° C.

Provenance & Evidence