Maleic Acid → HCID 12961952, compound

Participants

Reaction Steps

A solution of maleic acid (1.1 g) in ethanol (30 ml) was added to a solution of 17β-methylamino-5α-androstane-3β,16β-diol (3.05 g) in methanol (600 ml) and the solution was concentrated, treated with charcoal, and filtered. The filtrate was evaporated to give a froth (3.9 g), which crystallised from acetone to give 17β-methylamino-5α-androstane-3β,16β-diol (Z)-2-butenedioate (1:1) (salt) (3.19 g), m.p. 126°-129° C. and 184°-187° C., [α]D +21.2° (c 1.05 in MeOH).

Provenance & Evidence