Maleic Acid → HCID 12962055, compound

Participants

Reaction Steps

A solution of maleic acid (0.73 g) in ethanol (15 ml) was added to a solution of 16α-hyroxy-17β-methylamino-androst-4-en-3-one (2 g) in dichloromethane (15 ml) and ethanol (15 ml). Evaporation of the solvent gave a solid residue which was crystallised from dichloromethane-acetone to give 16α-hydroxy-17β-methylamino-androst-4-en-3-one (Z)-2-butenedioate as prisms (2.65 g), m.p. 193° C. (decomp.), [α]D +114° (c 0.88 in EtOH).

Provenance & Evidence