HuagongsheHuagongshe Chemistry Print Report · For research reference only
Maleic Acid → HCID 12961995, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Maleic Acid | HCID 444266 | — |
| Reactant | 17 beta-(Methylamino)estra-1(10),2,4-triene-3,16α-diol | HCID 9866663 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 12961995 | HCID 12961995 | — |
Reaction Steps
17β-Methylamino-oestra-1,3,5(10)-triene-3,16α-diol (1.7 g) was dissolved in dichloromethane (17 ml) and a solution of maleic acid (0.63 g) in methanol (6.3 ml) was added. The resulting solution was evaporated to low volume and acetone was added to give pure 17β-dimethylamino-oestra-1,3,5(10)-triene-3,16α-diol (Z)-2-butenedioate (1:1) (salt) as prisms (1.76 g; 75.5%), m.p. 188°-194° C., [α]D +36.1° (c 0.98 in MeOH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04330539 |
| Source dataset | uspto-grants-1982_05 |
| ORD ID | ord-af3da85507ec4234a2f84ef3251c48ae |
| Source note | uspto-grants-1982_05 |