HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 12962022, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Citric Acid | HCID 311 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | HCID 12962023 | HCID 12962023 | — |
| Reactant | HCID 86738380 | HCID 86738380 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 12962022 | HCID 12962022 | — |
Reaction Steps
In a similar way as described in Example XIII 3,16α-dihydroxy-oestra-1,3,5(10)-trien-17-one diacetate was converted with a saturated solution of ammonia in ethanol and in the presence of a type 3 A molecular sieve, followed by sodium borohydride reduction of the intermediate 17-imine, into 17β-amino-oestra-1,3,5(10)-triene-3,16α-diol. Reaction of the latter compound with citric acid gave 17β-amino-oestra-1,3,5(10)-triene-3,16α-diol citrate (1:1) (salt), m.p. >220° C. (decomp.), [α]D +24° (c 0.9 in dimethylsulphoxide).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04330539 |
| Source dataset | uspto-grants-1982_05 |
| ORD ID | ord-52a7e8a2dd6a44b2a7dc1c8f3fae88d7 |
| Source note | uspto-grants-1982_05 |