Hydroxide → N-[2-oxo-2-(pyrrolidin-3-ylamino)ethyl]-3-(trifluoromethyl)benzamide

HRID 106573Notes

Reaction equation

HRID 106573 reaction equation
[Cl:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][N:7]2[CH2:8][CH:9]([NH:12][C:13]([CH2:14][NH:15][C:16]([c:17]3[cH:18][c:19]([C:23]([F:24])([F:25])[F:26])[cH:20][cH:21][cH:22]3)=[O:27])=[O:28])[CH2:10][CH2:11]2)[cH:29][cH:30]1.[OH-:31].[OH-:32].[Pd+2:33]>>[NH:7]1[CH2:8][CH:9]([NH:12][C:13]([CH2:14][NH:15][C:16]([c:17]2[cH:18][c:19]([C:23]([F:24])([F:25])[F:26])[cH:20][cH:21][cH:22]2)=[O:27])=[O:28])[CH2:10][CH2:11]1

Participants

4

Reactant 3

HCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 9889422N-{[1-(4-Chloro-benzyl)-pyrrolidin-3-ylcarbamoyl]-methyl}-3-trifluoromethyl-benzamide

Product 1

HCID 18426146N-[2-oxo-2-(pyrrolidin-3-ylamino)ethyl]-3-(trifluoromethyl)benzamide

Sources & evidence

ORD record
ord-ba5f696f2acb47cca13b4c2780794ddb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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