HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Trifluoromethyl)aniline → N-(2,6-bis(trifluoromethyl)-4-pyridinyl)-N'-(4-trifluoromethylphenyl)thiourea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Trifluoromethyl)aniline | HCID 9964 | — |
| Reactant | 4-Isothiocyanato-2,6-bis(trifluoromethyl)pyridine | HCID 13373606 | — |
| Catalyst | Triethylamine | HCID 8471 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | N-(2,6-bis(trifluoromethyl)-4-pyridinyl)-N'-(4-trifluoromethylphenyl)thiourea | HCID 12945257 | 72.9% |
Reaction Steps
A mixture of 4-aminobenzotrifluoride (1.48 g) and 4-isothiocyanato-2,6-bis(trifluoromethyl)pyridine (2.5 g, 0.01 mole) in dry benzene (25 ml) containing several drops of triethylamine was heated under reflux for 7 hours. Removal of the solvent and triethylamine gave the title compound as a colorless solid 2.9 g, m.p. 125°-132° C. Crystallization from benzene furnished a sample, m.p. 132° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04331669 |
| Source dataset | uspto-grants-1982_05 |
| ORD ID | ord-a9778566bd43446ea18099feab076bc7 |
| Source note | uspto-grants-1982_05 |