Potassium Hydroxide → HCID 13646628, Verbindung

HRID 1065759Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1065759
[OH-].[K+].[N+:3]([CH:6]=[C:7](SC)[S:8]([CH3:10])=O)([O-:5])=[O:4].Cl.[NH2:14][CH2:15][C:16](=O)[CH3:17]>CO>[CH3:10][S:8][C:7]1[NH:14][CH:15]=[C:16]([CH3:17])[C:6]=1[N+:3]([O-:5])=[O:4]

Komponenten

5

Edukt 3

HCID 14797Potassium HydroxideHCID 30840252-Propanone, 1-amino-, hydrochlorideHCID 544870941-Nitro2-methylthio-2-methylsulphinylethylene

Produkt 1

HCID 13646628HCID 13646628, VerbindungAusbeute 16,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Crushed potassium hydroxide (5.7 g, 0.1 mol) was added portionwise to a refluxing solution of 1-nitro-2-methylthio-2-methylsulphinylethylene (9.3 g, 0.05 mol) and aminoacetone hydrochloride (5.6 g, 0.05 mol) in methanol (100 ml). Reflux was continued for 5 minutes, and then the mixture was cooled and the solvent removed in vacuo. Water was added to the residue, and the solid was recrystallised from chloroform/methanol/petroleum ether to give 2-methylthio-3-nitro-4-methylpyrrole (1.45 g, 16%) m.p. 216-216-5.

Aufarbeitung

  1. temperatureReflux
  2. temperaturethe mixture was cooled
  3. customthe solvent removed in vacuo
  4. additionWater was added to the residue
  5. customthe solid was recrystallised from chloroform/methanol/petroleum ether

Quellen und Nachweise

ORD-Eintrag
ord-41794ffd7e64416fb3a8d4ba8c152fc2
Quelldatensatz
uspto-grants-1982_05
Patentnummer
US04331668

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