Bromine → HCID 53994102, compound

HRID 1065783Notes

Reaction equation

HRID 1065783 reaction equation
[CH2:1]([O:3][C:4](=[O:19])[C:5]([CH3:18])([CH3:17])[C:6](=[O:16])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=1)[CH3:2].[Br:20]Br>C(Cl)(Cl)(Cl)Cl>[CH2:1]([O:3][C:4](=[O:19])[C:5]([CH3:18])([CH3:17])[C:6](=[O:16])[CH:7]([Br:20])[O:8][C:9]1[CH:10]=[CH:11][C:12]([Cl:15])=[CH:13][CH:14]=1)[CH3:2]

Participants

4

Reactant 2

HCID 24408Bromine2×HCID 53810952Ethyl 4-(4-chlorophenoxy)-2,2-dimethyl-3-oxobutanoate

Product 1

HCID 53994102HCID 53994102, compound

Reagents, catalysts & solvents 1

HCID 5943Carbon TetrachlorideSolvent2×

Procedure

26 g (0.091 mol) of 4-(4-chlorophenoxy)-2,2-dimethyl-3-keto-butanoic acid ethyl ester were dissolved in 150 ml of carbon tetrachloride. 4.7 ml (0.091 mol) of bromine in 50 ml of carbon tetrachloride were added dropwise at room temperature at such a rate that the bromine was steadily consumed. The mixture was then stirred for 30 minutes at room temperature. After distilling off the solvent in vacuo, 4-bromo-4-(4-chlorophenoxy)-2,2-dimethyl-3-keto-butanoic acid ethyl ester was obtained quantitatively and could directly be reacted further.

Workup

  1. customwas steadily consumed
  2. distillationAfter distilling off the solvent in vacuo

Sources & evidence

ORD record
ord-6ef0cfeeb7164d14b8dc77d7d62ea522
Source dataset
uspto-grants-1982_05
Patent number
US04331674

Reaction notes

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