Sodium Bicarbonate → HCID 54350404, compound

Participants

Reaction Steps

B 122.5 g (0.248 mol) of 4-(4-chlorophenoxy)-2,2-dimethyl-4-(imidazol-1-yl)-3-keto-butanoic acid ethyl ester 1,5-naphthalenedisulphonate (see Example 2) were suspended in 500 ml of methylene chloride and the suspension was stirred with 1,000 ml of saturated sodium bicarbonate solution for 0.5 hour. The organic phase was separated off, dried over sodium sulphate and concentrated. The residue crystallized on heating with 200 ml of petroleum ether. 85 g (98% of theory) of 4-(4-chlorophenoxy)-2,2-dimethyl-4-(imidazol-1-yl)-3-keto-butanoic acid ethyl ester of melting point 88° C. were obtained.

Provenance & Evidence